I've always had a fondness for Circe. Waterhouse painted her poisoning the sea.

...While Scylla bathed in a small spring, the jealous Circe poured a potion of herbs into the water, then cast her spell. From the lower half of her body Scylla grew six monstrous dogs, but the upper half remained intact...



Notice the skull by her feet.

John William Waterhouse: Circe Invidiosa - 1892 « Paintings