I think about moderation in terms of being at balance. For instance, drugs are good, but too many can fuck you up permanently AND restrict you from experiencing other things as well..
The paradox isn't quite there with me. Maybe because I'm claiming that I don't really do anything for myself (which is the root of a lot of my unhappiness, I admit)...and that changed when I started to commit to my personal growth. The trick is balance...moderation...and I still have fun thank-you-very-much! I see a lot of people who put themselves through needless suffering because of impatience and ambitious desires and whatnot...but that's a judgement in the end...
I think a lot of people get caught up in the semantics of what "losing your Self" is... understanding the basic concept of the Self isn't that difficult, but then people look at the lifestyle of Bhuddists, for instance, and say "I don't want to live that way! etc".. which isn't necessary.
Science will kill us just as quickly as it saves us. Same idea concerning guns: it's harmless as a tool but in the hands of a killer, it's a weapon. In the hands of a pacifist, it's scrap metal...in that vein, it comes down to who controls the technology that science grants us. Which leads to motives and politicians and power and seductive sexy women and movies with George Clooney....er. sorry.
I think we're on the same level though. nod-nod.