Gentoo is piss easy to use, just as easy as standard gnome or kde, or whatever desktop you choose to use (or not), its the install and config that's awkward, well the config that's awkward, installing new stuff is just very time-consuming. You get one hell of a system though, set up just how you want it.

I'll probably use Gentoo again when they transfer the 2.6 kernel to gentoo-sources.